About Interleukin-6
Interleukin-6 (IL6) is a protein
from Homo sapiens identified by UniProt accession
P05231, 212 residues long.
MolForge cross-references it against 0 known binders and
3,025 disease associations.
Target properties
| Protein name | Interleukin-6 |
|---|
| UniProt accession | P05231 |
|---|
| Gene | IL6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 212 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (3025)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.51
- immune system disease · score 0.47
- Giant Lymph Node Hyperplasia · score 0.46
- asthma · score 0.45
- Kaposi's sarcoma · score 0.42
- eosinophil count · score 0.39
- juvenile idiopathic arthritis · score 0.38
- systemic juvenile idiopathic arthritis · score 0.38
- C-reactive protein measurement · score 0.38
- COVID-19 · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05231-F1 | alphafold | PREDICTED | 85.29 | — |
Amino-acid sequence (212 residues)
MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL IQFLQKKAKN LDAITTPDPT TNASLLTKLQ AQNQWLQDMT THLILRSFKE FLQSSLRALR QM
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