Prednisolone

Corticosteroid — ALIMENTARY TRACT AND METABOLISM

Key facts

Prednisolone is an ofp drug in the Corticosteroid class catalogued in DrugCentral. It was first approved by the FDA in 1955. Its mechanism of action is classified as Corticosteroid Hormone Receptor Agonists. DrugCentral lists 14 molecular targets, including NR3C2, Nr3c1 and IL6. Recorded indications include Acquired thrombocytopenia, Acute lymphoid leukemia, Adrenal cortical hypofunction and Adrenogenital disorder.

• Approval status: ofp (first approved 1955 by the FDA).
• Drug class: Corticosteroid.
• Mechanism of action: Corticosteroid Hormone Receptor Agonists.
• Molecular targets: NR3C2, Nr3c1, IL6 and ADAM17 (14 listed in DrugCentral).
• Indications: Acquired thrombocytopenia, Acute lymphoid leukemia, Adrenal cortical hypofunction, Adrenogenital disorder and Allergic bronchopulmonary aspergillosis and others.
• ATC code: A01AC04 (Corticosteroids for local oral treatment).
• Molecular formula: C21H28O5; molecular weight 360.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (100)

• Acquired thrombocytopenia
• Acute lymphoid leukemia
• Adrenal cortical hypofunction
• Adrenogenital disorder
• Allergic bronchopulmonary aspergillosis
• Allergic conjunctivitis
• Allergic rhinitis
• Angioedema
• Ankylosing spondylitis
• Articular gout
• Aspiration pneumonitis
• Asthma
• Atopic dermatitis
• Autoimmune disease
• Autoimmune hemolytic anemia
• Bacterial conjunctivitis
• Bacterial keratitis
• Berylliosis
• Blepharoconjunctivitis
• Bursitis
• Cerebral edema
• Congenital adrenal hyperplasia
• Congenital hypoplastic anemia
• Contact dermatitis
• Corneal abrasion
• Corneal ulcer
• Crohn's disease
• Cyclitis
• Dacryocystitis
• Dermatitis herpetiformis
• + 70 more

Mechanism & targets

• Mechanism of action (MoA): Corticosteroid Hormone Receptor Agonists
• Established pharmacologic class: Corticosteroid

Molecular targets (14)

Target	Gene	Action	Activity
Mineralocorticoid receptor	NR3C2	unknown	Ki 9.54
Glucocorticoid receptor	Nr3c1	unknown	EC50 8.47
Interleukin-6	IL6	unknown	IC50 8.38
Disintegrin and metalloproteinase domain-containing protein 17	ADAM17	unknown	IC50 7.83
Glucocorticoid receptor	NR3C1	agonist	EC50 7.80
Corticosteroid-binding globulin	SERPINA6	unknown	Ki 7.51
Glutamine synthetase	GLUL	unknown	EC50 7.49
Glucocorticoid receptor	Nr3c1	unknown	IC50 7.28
G-protein coupled bile acid receptor 1	GPBAR1	unknown	IC50 6.60
Tumor necrosis factor	TNF	unknown	IC50 6.60
Progesterone receptor	PGR	unknown	IC50 5.68
Androgen receptor	AR	unknown	Ki 5.60
Fatty acid-binding protein, liver	Fabp1	unknown	Ki 5.58
Annexin A1	ANXA1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1955-06-21	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A01AC04	ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Corticosteroids for local oral treatment
A01AC54	ALIMENTARY TRACT AND METABOLISM › STOMATOLOGICAL PREPARATIONS › STOMATOLOGICAL PREPARATIONS › Corticosteroids for local oral treatment
A07EA01	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFLAMMATORY AGENTS › Corticosteroids acting locally
C05AA04	CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Corticosteroids
D07AA03	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, PLAIN › Corticosteroids, weak (group I)
D07BA01	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS › Corticosteroids, weak, combinations with antiseptics
D07CA03	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS › Corticosteroids, weak, combinations with antibiotics
D07XA02	DERMATOLOGICALS › CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS › CORTICOSTEROIDS, OTHER COMBINATIONS › Corticosteroids, weak, other combinations
H02AB06	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN › Glucocorticoids
R01AD02	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Corticosteroids

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Pneumocystis jirovecii pneumonia	2933.4
Cytomegalovirus infection	2858.7
Fatigue	1409.9
Transplant rejection	1342.0
Pain	1259.2
Product dose omission issue	1217.4
Post transplant lymphoproliferative disorder	1167.8
Sepsis	1043.5
Interstitial lung disease	995.4
Off label use	973.5
Bronchopulmonary aspergillosis	958.4
Epstein-Barr virus infection	950.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Prednisolone is on its molecule page.

• Molecular formula: C₂₁H₂₈O₅
• Molecular weight: 360.45 g/mol
• CAS number: 50-24-8
• InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• PubChem CID: 5755

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Prednisolone used for?

DrugCentral lists the following indications for Prednisolone: Acquired thrombocytopenia, Acute lymphoid leukemia, Adrenal cortical hypofunction, Adrenogenital disorder, Allergic bronchopulmonary aspergillosis, Allergic conjunctivitis, Allergic rhinitis and Angioedema and others.

How does Prednisolone work?

Prednisolone is classified as Corticosteroid Hormone Receptor Agonists; its molecular targets in DrugCentral include NR3C2, Nr3c1, IL6 and ADAM17.

When was Prednisolone first approved?

Prednisolone was first approved by the FDA in 1955.

What drug class does Prednisolone belong to?

Prednisolone is in the Corticosteroid class.

What is the chemical formula of Prednisolone?

Prednisolone has the molecular formula C21H28O5 and a molecular weight of 360.45 g/mol.

Sources

• DrugCentral drug card 2245 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL131 — compound record and bioactivity
• PubChem CID 5755 — chemical identifiers
• DrugBank DB00860 — drug record
• FDA UNII 9PHQ9Y1OLM — substance identity
• DailyMed: FDA labels for Prednisolone — current prescribing information (label search)
• UniProt P08235 (NR3C2) — target protein
• UniProt P05231 (IL6) — target protein
• UniProt P78536 (ADAM17) — target protein
• UniProt P04150 (NR3C1) — target protein
• UniProt P08185 (SERPINA6) — target protein
• UniProt P15104 (GLUL) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.