About Tumor necrosis factor
Tumor necrosis factor (TNF) is a protein
from Homo sapiens identified by UniProt accession
P01375, 233 residues long.
MolForge cross-references it against 0 known binders and
3,506 disease associations.
Target properties
| Protein name | Tumor necrosis factor |
|---|
| UniProt accession | P01375 |
|---|
| Gene | TNF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 233 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (12)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (3506)
Diseases linked to this target (Open Targets).
- psoriatic arthritis · score 0.70
- psoriasis · score 0.64
- ulcerative colitis · score 0.64
- rheumatoid arthritis · score 0.63
- Crohn's disease · score 0.62
- ankylosing spondylitis · score 0.62
- juvenile idiopathic arthritis · score 0.60
- inflammatory bowel disease · score 0.60
- spondyloarthropathy · score 0.59
- uveitis · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P01375-F1 | alphafold | PREDICTED | 84.56 | — |
Amino-acid sequence (233 residues)
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
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