Glutamine synthetase (GLUL)

About Glutamine synthetase

Glutamine synthetase (GLUL) is a protein from Homo sapiens identified by UniProt accession P15104, 373 residues long. MolForge cross-references it against 0 known binders and 361 disease associations.

Target properties

Protein name	Glutamine synthetase
UniProt accession	P15104
Gene	GLUL
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (361)

Diseases linked to this target (Open Targets).

congenital brain dysgenesis due to glutamine synthetase deficiency · score 0.77
neurodegenerative disease · score 0.52
developmental and epileptic encephalopathy · score 0.49
progressive myoclonic epilepsy with dystonia · score 0.49
malignant migrating partial seizures of infancy · score 0.49
Seizure · score 0.37
Red cell distribution width · score 0.33
high density lipoprotein cholesterol measurement · score 0.22
lymphocyte count · score 0.21
leukocyte count · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P15104-F1	alphafold	PREDICTED	97.53	—

Amino-acid sequence (373 residues)

MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS VTEALIRTCL LNETGDEPFQ YKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards