G-protein coupled bile acid receptor 1 (GPBAR1)

About G-protein coupled bile acid receptor 1

G-protein coupled bile acid receptor 1 (GPBAR1) is a protein from Homo sapiens identified by UniProt accession Q8TDU6, 330 residues long. MolForge cross-references it against 0 known binders and 334 disease associations.

Target properties

Protein name	G-protein coupled bile acid receptor 1
UniProt accession	Q8TDU6
Gene	GPBAR1
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (334)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.27
monocyte count · score 0.25
neutrophil count · score 0.23
glioblastoma multiforme · score 0.23
leukocyte count · score 0.21
cholelithiasis · score 0.18
vital capacity · score 0.18
gallbladder disease · score 0.18
reticulocyte count · score 0.18
biliary tract disease · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDU6-F1	alphafold	PREDICTED	80.42	—

Amino-acid sequence (330 residues)

MTPNSTGEVP SPIPKGALGL SLALASLIIT ANLLLALGIA WDRRLRSPPA GCFFLSLLLA GLLTGLALPT LPGLWNQSRR GYWSCLLVYL APNFSFLSLL ANLLLVHGER YMAVLRPLQP PGSIRLALLL TWAGPLLFAS LPALGWNHWT PGANCSSQAI FPAPYLYLEV YGLLLPAVGA AAFLSVRVLA TAHRQLQDIC RLERAVCRDE PSALARALTW RQARAQAGAM LLFGLCWGPY VATLLLSVLA YEQRPPLGPG TLLSLLSLGS ASAAAVPVAM GLGDQRYTAP WRAAAQRCLQ GLWGRASRDS PGPSIAYHPS SQSSVDLDLN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards