Lupus La protein (SSB)

About Lupus La protein

Lupus La protein (SSB) is a protein from Homo sapiens identified by UniProt accession P05455, 408 residues long. MolForge cross-references it against 0 known binders and 357 disease associations.

Target properties

Protein name	Lupus La protein
UniProt accession	P05455
Gene	SSB
Organism	Homo sapiens
Length	408 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (357)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
Parkinson disease · score 0.23
multiple sclerosis · score 0.23
lysosomal storage disease · score 0.23
Alzheimer disease · score 0.23
serum alanine aminotransferase measurement · score 0.11
platelet count · score 0.10
infection · score 0.09
infect · score 0.09
cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05455-F1	alphafold	PREDICTED	74.52	—

Amino-acid sequence (408 residues)

MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LEDKGQVLNI QMRRTLHKAF KGSIFVVFDS IESAKKFVET PGQKYKETDL LILFKDDYFA KKNEERKQNK VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL DDQTCREDLH ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS GKGKVQFQGK KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK TENGAGDQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards