About DNA polymerase beta
DNA polymerase beta (POLB) is a protein
from Homo sapiens identified by UniProt accession
P06746, 335 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | DNA polymerase beta |
|---|
| UniProt accession | P06746 |
|---|
| Gene | POLB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 335 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (181)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- breast adenocarcinoma · score 0.25
- ovarian cancer · score 0.23
- endometrial cancer · score 0.10
- body height · score 0.09
- hepatocellular carcinoma · score 0.08
- tissue plasminogen activator measurement · score 0.07
- breast ductal carcinoma in situ · score 0.07
- lymphatic system disease · score 0.06
- autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06746-F1 | alphafold | PREDICTED | 94.25 | — |
Amino-acid sequence (335 residues)
MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL TRVSGIGPSA ARKFVDEGIK TLEDLRKNED KLNHHQRIGL KYFGDFEKRI PREEMLQMQD IVLNEVKKVD SEYIATVCGS FRRGAESSGD MDVLLTHPSF TSESTKQPKL LHQVVEQLQK VHFITDTLSK GETKFMGVCQ LPSKNDEKEY PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP LGVTGVAGEP LPVDSEKDIF DYIQWKYREP KDRSE
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