About Lipoprotein lipase
Lipoprotein lipase (LPL) is a protein
from Homo sapiens identified by UniProt accession
P06858, 475 residues long.
MolForge cross-references it against 0 known binders and
597 disease associations.
Target properties
| Protein name | Lipoprotein lipase |
|---|
| UniProt accession | P06858 |
|---|
| Gene | LPL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 475 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (597)
Diseases linked to this target (Open Targets).
- familial lipoprotein lipase deficiency · score 0.84
- Hyperlipoproteinemia type 1 · score 0.80
- Combined hyperlipidemia · score 0.75
- high density lipoprotein cholesterol measurement · score 0.72
- triglyceride measurement · score 0.70
- lipoprotein measurement · score 0.65
- triglyceride:HDL cholesterol ratio · score 0.57
- triglycerides:total lipids ratio · score 0.57
- Hyperapobetalipoproteinemia · score 0.56
- Abnormality of the cardiovascular system · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P06858-F1 | alphafold | PREDICTED | 91.05 | — |
Amino-acid sequence (475 residues)
MESKALLVLT LAVWLQSLTA SRGGVAAADQ RRDFIDIESK FALRTPEDTA EDTCHLIPGV AESVATCHFN HSSKTFMVIH GWTVTGMYES WVPKLVAALY KREPDSNVIV VDWLSRAQEH YPVSAGYTKL VGQDVARFIN WMEEEFNYPL DNVHLLGYSL GAHAAGIAGS LTNKKVNRIT GLDPAGPNFE YAEAPSRLSP DDADFVDVLH TFTRGSPGRS IGIQKPVGHV DIYPNGGTFQ PGCNIGEAIR VIAERGLGDV DQLVKCSHER SIHLFIDSLL NEENPSKAYR CSSKEAFEKG LCLSCRKNRC NNLGYEINKV RAKRSSKMYL KTRSQMPYKV FHYQVKIHFS GTESETHTNQ AFEISLYGTV AESENIPFTL PEVSTNKTYS FLIYTEVDIG ELLMLKLKWK SDSYFSWSDW WSSPGFAIQK IRVKAGETQK KVIFCSREKV SHLQKGKAPA VFVKCHDKSL NKKSG
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