Involucrin (IVL)

About Involucrin

Involucrin (IVL) is a protein from Homo sapiens identified by UniProt accession P07476, 585 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	Involucrin
UniProt accession	P07476
Gene	IVL
Organism	Homo sapiens
Length	585 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
breast adenocarcinoma · score 0.22
head and neck squamous cell carcinoma · score 0.19
clear cell renal carcinoma · score 0.18
ovarian cancer · score 0.18
esophageal cancer · score 0.17
gastric adenocarcinoma · score 0.16
blood protein measurement · score 0.15
squamous cell lung carcinoma · score 0.11
endometrial cancer · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P07476-F1	alphafold	PREDICTED	49.43	—

Amino-acid sequence (585 residues)

MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards