About Signal recognition particle receptor subunit alpha
Signal recognition particle receptor subunit alpha (SRPRA) is a protein
from Homo sapiens identified by UniProt accession
P08240, 638 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Signal recognition particle receptor subunit alpha |
|---|
| UniProt accession | P08240 |
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| Gene | SRPRA |
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| Organism | Homo sapiens |
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| Length | 638 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- severe congenital neutropenia · score 0.38
- Shwachman-Diamond syndrome · score 0.33
- endometrial cancer · score 0.11
- autism spectrum disorder · score 0.09
- eosinophil percentage of leukocytes · score 0.07
- eosinophil percentage of granulocytes · score 0.07
- eosinophil count · score 0.06
- lymphocyte percentage of leukocytes · score 0.06
- body height · score 0.05
- neutrophil count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08240-F1 | alphafold | PREDICTED | 73.73 | — |
Amino-acid sequence (638 residues)
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR SMIETRGEKP KEKAKNSKKK GAKKEGSDGP LATSKPVPAE KSGLPVGPEN GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK GKKAPRVWEL GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI AKNVAADIAV QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ RRVDMLRDIM DAQRRQRPYV VTFCGVNGVG KSTNLAKISF WLLENGFSVL IAACDTFRAG AVEQLRTHTR RLSALHPPEK HGGRTMVQLF EKGYGKDAAG IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT VNTPDLVLFV GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA
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