Synaptophysin (SYP)

About Synaptophysin

Synaptophysin (SYP) is a protein from Homo sapiens identified by UniProt accession P08247, 313 residues long. MolForge cross-references it against 0 known binders and 524 disease associations.

Target properties

Protein name	Synaptophysin
UniProt accession	P08247
Gene	SYP
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (524)

Diseases linked to this target (Open Targets).

X-linked non-syndromic intellectual disability · score 0.72
neurodegenerative disease · score 0.37
Neurodevelopmental delay · score 0.27
non-syndromic X-linked intellectual disability · score 0.18
genetic disorder · score 0.17
neoplasm · score 0.11
attention deficit hyperactivity disorder · score 0.09
attention deficit-hyperactivity disorder 8 · score 0.09
schizophrenia 15 · score 0.08
breast cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08247-F1	alphafold	PREDICTED	76.73	—

Amino-acid sequence (313 residues)

MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYSGE LQLSVDCANK TESDLSIEVE FEYPFRLHQV YFDAPTCRGG TTKVFLVGDY SSSAEFFVTV AVFAFLYSMG ALATYIFLQN KYRENNKGPM LDFLATAVFA FMWLVSSSAW AKGLSDVKMA TDPENIIKEM PVCRQTGNTC KELRDPVTSG LNTSVVFGFL NLVLWVGNLW FVFKETGWAA PFLRAPPGAP EKQPAPGDAY GDAGYGQGPG GYGPQDSYGP QGGYQPDYGQ PAGSGGSGYG PQGDYGQQGY GPQGAPTSFS NQM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards