About 72 kDa type IV collagenase
72 kDa type IV collagenase (MMP2) is a protein
from Homo sapiens identified by UniProt accession
P08253, 660 residues long.
MolForge cross-references it against 0 known binders and
1,542 disease associations.
Target properties
| Protein name | 72 kDa type IV collagenase |
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| UniProt accession | P08253 |
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| Gene | MMP2 |
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| Organism | Homo sapiens |
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| Length | 660 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (14)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1542)
Diseases linked to this target (Open Targets).
- Torg-Winchester syndrome · score 0.75
- multicentric osteolysis-nodulosis-arthropathy spectrum · score 0.63
- Nodulosis-arthropathy-osteolysis syndrome · score 0.55
- heel bone mineral density · score 0.37
- lip and oral cavity carcinoma · score 0.34
- lung cancer · score 0.34
- bone quantitative ultrasound measurement · score 0.33
- breast cancer · score 0.31
- body height · score 0.27
- Gitelman syndrome · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08253-F1 | alphafold | PREDICTED | 89.73 | — |
Amino-acid sequence (660 residues)
MEALMARGAL TGPLRALCLL GCLLSHAAAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD KNQITYRIIG YTPDLDPETV DDAFARAFQV WSDVTPLRFS RIHDGEADIM INFGRWEHGD GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN GKEYNSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNAEGQP CKFPFRFQGT SYDSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY ESCTSAGRSD GKMWCATTAN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL MAPIYTYTKN FRLSQDDIKG IQELYGASPD IDLGTGPTPT LGPVTPEICK QDIVFDGIAQ IRGEIFFFKD RFIWRTVTPR DKPMGPLLVA TFWPELPEKI DAVYEAPQEE KAVFFAGNEY WIYSASTLER GYPKPLTSLG LPPDVQRVDA AFNWSKNKKT YIFAGDKFWR YNEVKKKMDP GFPKLIADAW NAIPDNLDAV VDLQGGGHSY FFKGAYYLKL ENQSLKSVKF GSIKSDWLGC
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