Stromelysin-1 (MMP3)

About Stromelysin-1

Stromelysin-1 (MMP3) is a protein from Homo sapiens identified by UniProt accession P08254, 477 residues long. MolForge cross-references it against 0 known binders and 848 disease associations.

Target properties

Protein name	Stromelysin-1
UniProt accession	P08254
Gene	MMP3
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (848)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.48
matrix metalloproteinase measurement · score 0.47
coronary artery disease · score 0.42
matrix metalloproteinase 12 measurement · score 0.38
matrix metalloproteinase 1 measurement · score 0.34
lung cancer · score 0.32
Alzheimer disease · score 0.32
Alzheimer's disease biomarker measurement · score 0.32
breast cancer · score 0.28
peripheral arterial disease · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P08254-F1	alphafold	PREDICTED	85.71	—

Amino-acid sequence (477 residues)

MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLKKDVKQ FVRRKDSGPV VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF RTFPGIPKWR KTHLTYRIVN YTPDLPKDAV DSAVEKALKV WEEVTPLTFS RLYEGEADIM ISFAVREHGD FYPFDGPGNV LAHAYAPGPG INGDAHFDDD EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY HSLTDLTRFR LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS TLRGEILIFK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD LVFIFKGNQF WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT YFFVEDKYWR FDEKRNSMEP GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF TGSSQLEFDP NAKKVTHTLK SNSWLNC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards