About Signal recognition particle 19 kDa protein
Signal recognition particle 19 kDa protein (SRP19) is a protein
from Homo sapiens identified by UniProt accession
P09132, 144 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | Signal recognition particle 19 kDa protein |
|---|
| UniProt accession | P09132 |
|---|
| Gene | SRP19 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 144 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- familial adenomatous polyposis 1 · score 0.42
- severe congenital neutropenia · score 0.38
- autosomal dominant severe congenital neutropenia · score 0.37
- Shwachman-Diamond syndrome · score 0.33
- neurodegenerative disease · score 0.28
- body mass index · score 0.24
- cortical surface area measurement · score 0.19
- heel bone mineral density · score 0.18
- bone density · score 0.18
- fat body mass · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09132-F1 | alphafold | PREDICTED | 85.84 | — |
Amino-acid sequence (144 residues)
MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNV FLEKNKMYSR EWNRDVQYRG RVRVQLKQED GSLCLVQFPS RKSVMLYAAE MIPKLKTRTQ KTGGADQSLQ QGEGSKKGKG KKKK
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