About Intestinal-type alkaline phosphatase
Intestinal-type alkaline phosphatase (ALPI) is a protein
from Homo sapiens identified by UniProt accession
P09923, 528 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Intestinal-type alkaline phosphatase |
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| UniProt accession | P09923 |
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| Gene | ALPI |
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| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (110)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.50
- neurodegenerative disease · score 0.36
- blood protein measurement · score 0.24
- neuroinflammatory disorder · score 0.22
- cutaneous melanoma · score 0.18
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- refractive error measurement · score 0.17
- DNA methylation · score 0.17
- bilirubin measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09923-F1 | alphafold | PREDICTED | 93.10 | — |
Amino-acid sequence (528 residues)
MQGPWVLLLL GLRLQLSLGV IPAEEENPAF WNRQAAEALD AAKKLQPIQK VAKNLILFLG DGLGVPTVTA TRILKGQKNG KLGPETPLAM DRFPYLALSK TYNVDRQVPD SAATATAYLC GVKANFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKQAGK SVGVVTTTRV QHASPAGTYA HTVNRNWYSD ADMPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPADA SQNGIRLDGK NLVQEWLAKH QGAWYVWNRT ELMQASLDQS VTHLMGLFEP GDTKYEIHRD PTLDPSLMEM TEAALRLLSR NPRGFYLFVE GGRIDHGHHE GVAYQALTEA VMFDDAIERA GQLTSEEDTL TLVTADHSHV FSFGGYTLRG SSIFGLAPSK AQDSKAYTSI LYGNGPGYVF NSGVRPDVNE SESGSPDYQQ QAAVPLSSET HGGEDVAVFA RGPQAHLVHG VQEQSFVAHV MAFAACLEPY TACDLAPPAC TTDAAHPVAA SLPLLAGTLL LLGASAAP
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