Phenylalanine

Drug profile

Key facts

Phenylalanine is a drug catalogued in DrugCentral. DrugCentral lists 8 molecular targets, including PKM, Cacna2d1 and GPR139.

• Molecular targets: PKM, Cacna2d1, GPR139 and Slc7a5 (8 listed in DrugCentral).
• Molecular formula: C9H11NO2; molecular weight 165.19 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (11)

• Classical phenylketonuria
• End stage renal disease
• Heart disease
• Humoral hypercalcemia of malignancy
• Hypercalcemia
• Hypercalciuria
• Kidney disease
• Kidney stone
• Poisoning by digitalis glycoside
• Sarcoidosis
• Ventricular fibrillation

Mechanism & targets

Molecular targets (8)

Target	Gene	Action	Activity
Pyruvate kinase PKM	PKM	unknown	IC50 10.26
Voltage-dependent calcium channel subunit alpha-2/delta-1	Cacna2d1	unknown	Ki 6.01
Probable G-protein coupled receptor 139	GPR139	agonist	IC50 4.51
L-type amino acid transporter 1	Slc7a5	unknown	Ki 4.26
Large neutral amino acids transporter small subunit 1	SLC7A5	unknown	IC50 4.16
E3 ubiquitin-protein ligase XIAP	XIAP	unknown	IC50 4.10
Intestinal alkaline phosphatase	ALPI	unknown	IC50 4.10
Intestinal-type alkaline phosphatase	ALPI	unknown	IC50 4.00

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Foetal growth restriction	67.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Phenylalanine is on its molecule page.

• Molecular formula: C₉H₁₁NO₂
• Molecular weight: 165.19 g/mol
• CAS number: 63-91-2
• InChIKey: COLNVLDHVKWLRT-QMMMGPOBSA-N
• PubChem CID: 6140

N[C@@H](CC1=CC=CC=C1)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Phenylalanine work?

Its molecular targets in DrugCentral include PKM, Cacna2d1, GPR139 (agonist) and Slc7a5.

What is the chemical formula of Phenylalanine?

Phenylalanine has the molecular formula C9H11NO2 and a molecular weight of 165.19 g/mol.

Sources

• DrugCentral drug card 2144 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL301523 — compound record and bioactivity
• PubChem CID 6140 — chemical identifiers
• DrugBank DB00120 — drug record
• FDA UNII 47E5O17Y3R — substance identity
• DailyMed: FDA labels for Phenylalanine — current prescribing information (label search)
• UniProt P14618 (PKM) — target protein
• UniProt Q6DWJ6 (GPR139) — target protein
• UniProt Q01650 (SLC7A5) — target protein
• UniProt P98170 (XIAP) — target protein
• UniProt P09923 (ALPI) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.