Probable G-protein coupled receptor 139 (GPR139)
Homo sapiens — UniProt Q6DWJ6
Data last refreshed: (UniProt release unknown)
Key facts
Probable G-protein coupled receptor 139 (GPR139) is a protein from Homo sapiens identified by UniProt accession Q6DWJ6, 353 residues long. MolForge cross-references it against 2 known binders and 54 disease associations.
- UniProt accession: Q6DWJ6; gene symbol GPR139.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Approved drugs acting on it (DrugCentral): Tryptophan and Phenylalanine.
- Top disease associations (Open Targets): testosterone measurement, lean body mass and body weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable G-protein coupled receptor 139 |
|---|---|
| UniProt accession | Q6DWJ6 |
| Gene | GPR139 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (54)
Diseases linked to this target (Open Targets).
- testosterone measurement · score 0.49
- lean body mass · score 0.48
- body weight · score 0.44
- alcohol consumption measurement · score 0.38
- appendicular lean mass · score 0.36
- fat body mass · score 0.35
- base metabolic rate measurement · score 0.32
- whole body water mass · score 0.32
- birth weight · score 0.32
- body mass index · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6DWJ6-F1 | alphafold | PREDICTED | 77.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6DWJ6.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target GPR139?
DrugCentral lists 2 approved drugs whose mechanism of action is GPR139: Tryptophan and Phenylalanine.
Which diseases are associated with GPR139?
The strongest Open Targets associations for GPR139 are testosterone measurement, lean body mass, body weight, alcohol consumption measurement and appendicular lean mass.
How long is the GPR139 protein?
The Homo sapiens GPR139 protein (UniProt Q6DWJ6) is 353 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6DWJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6DWJ6 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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