About Pyruvate kinase PKM
Pyruvate kinase PKM (PKM) is a protein
from Homo sapiens identified by UniProt accession
P14618, 531 residues long.
MolForge cross-references it against 0 known binders and
460 disease associations.
Target properties
| Protein name | Pyruvate kinase PKM |
|---|
| UniProt accession | P14618 |
|---|
| Gene | PKM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 531 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (460)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- neuroinflammatory disorder · score 0.37
- brain measurement · score 0.22
- erythrocyte count · score 0.16
- urate measurement · score 0.15
- forced expiratory volume · score 0.14
- neoplasm · score 0.12
- hepatocellular carcinoma · score 0.12
- endometrial cancer · score 0.12
- cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14618-F1 | alphafold | PREDICTED | 96.84 | — |
Amino-acid sequence (531 residues)
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICT IGPASRSVET LKEMIKSGMN VARLNFSHGT HEYHAETIKN VRTATESFAS DPILYRPVAV ALDTKGPEIR TGLIKGSGTA EVELKKGATL KITLDNAYME KCDENILWLD YKNICKVVEV GSKIYVDDGL ISLQVKQKGA DFLVTEVENG GSLGSKKGVN LPGAAVDLPA VSEKDIQDLK FGVEQDVDMV FASFIRKASD VHEVRKVLGE KGKNIKIISK IENHEGVRRF DEILEASDGI MVARGDLGIE IPAEKVFLAQ KMMIGRCNRA GKPVICATQM LESMIKKPRP TRAEGSDVAN AVLDGADCIM LSGETAKGDY PLEAVRMQHL IAREAEAAIY HLQLFEELRR LAPITSDPTE ATAVGAVEAS FKCCSGAIIV LTKSGRSAHQ VARYRPRAPI IAVTRNPQTA RQAHLYRGIF PVLCKDPVQE AWAEDVDLRV NFAMNVGKAR GFFKKGDVVI VLTGWRPGSG FTNTMRVVPV P
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