About E3 ubiquitin-protein ligase XIAP
E3 ubiquitin-protein ligase XIAP (XIAP) is a protein
from Homo sapiens identified by UniProt accession
P98170, 497 residues long.
MolForge cross-references it against 0 known binders and
572 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase XIAP |
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| UniProt accession | P98170 |
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| Gene | XIAP |
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| Organism | Homo sapiens |
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| Length | 497 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (572)
Diseases linked to this target (Open Targets).
- X-linked lymphoproliferative disease · score 0.77
- neurodegenerative disease · score 0.56
- inflammatory bowel disease · score 0.47
- Splenomegaly · score 0.46
- lymphoproliferative syndrome · score 0.40
- Sepsis · score 0.34
- Recurrent infections · score 0.34
- autoinflammatory syndrome · score 0.32
- ovarian cancer · score 0.25
- low grade glioma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P98170-F1 | alphafold | PREDICTED | 74.25 | — |
Amino-acid sequence (497 residues)
MTFNSFEGSK TCVPADINKE EEFVEEFNRL KTFANFPSGS PVSASTLARA GFLYTGEGDT VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYLEN SATQSTNSGI QNGQYKVENY LGSRDHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM YSEEARLKSF QNWPDYAHLT PRELASAGLY YTGIGDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE SDAVSSDRNF PNSTNLPRNP SMADYEARIF TFGTWIYSVN KEQLARAGFY ALGEGDKVKC FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE CLVRTTEKTP SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS GSNYKSLEVL VADLVNAQKD SMQDESSQTS LQKEISTEEQ LRRLQEEKLC KICMDRNIAI VFVPCGHLVT CKQCAEAVDK CPMCYTVITF KQKIFMS
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