About Leukotriene A-4 hydrolase
Leukotriene A-4 hydrolase (LTA4H) is a protein
from Homo sapiens identified by UniProt accession
P09960, 611 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Leukotriene A-4 hydrolase |
|---|
| UniProt accession | P09960 |
|---|
| Gene | LTA4H |
|---|
| Organism | Homo sapiens |
|---|
| Length | 611 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (147)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.33
- small intestine neuroendocrine tumor · score 0.27
- monocyte count · score 0.27
- protein measurement · score 0.26
- amino acid measurement · score 0.26
- blood metabolite measurement · score 0.26
- cutaneous melanoma · score 0.13
- acute myeloid leukemia · score 0.10
- COVID-19 · score 0.10
- insomnia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P09960-F1 | alphafold | PREDICTED | 96.27 | — |
Amino-acid sequence (611 residues)
MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT AMLVGKDLKV D
Explore Leukotriene A-4 hydrolase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets