Serine/threonine-protein kinase SBK2 (SBK2)

About Serine/threonine-protein kinase SBK2

Serine/threonine-protein kinase SBK2 (SBK2) is a protein from Homo sapiens identified by UniProt accession P0C263, 348 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase SBK2
UniProt accession	P0C263
Gene	SBK2
Organism	Homo sapiens
Length	348 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
plasma fibronectin deficiency · score 0.07
isolated asymptomatic elevation of creatine phosphokinase · score 0.06
Hereditary persistence of alpha-fetoprotein · score 0.04
congenital lethal erythroderma · score 0.04
Congenital deficiency in alpha-fetoprotein · score 0.03
lean body mass · score 0.02
neoplasm · score 0.01
multiple sclerosis · score 0.01
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C263-F1	alphafold	PREDICTED	89.58	—

Amino-acid sequence (348 residues)

MPGKQSEEGP AEAGASEDSE EEGLGGLTLE ELQQGQEAAR ALEDMMTLSA QTLVRAEVDE LYEEVRPLGQ GCYGRVLLVT HRQKGTPLAL KQLPKPRTSL RGFLYEFCVG LSLGAHSAIV TAYGIGIESA HSYSFLTEPV LHGDLMAFIQ PKVGLPQPAV HRCAAQLASA LEYIHARGLV YRDLKPENVL VCDPACRRFK LTDFGHTRPR GTLLRLAGPP IPYTAPELCA PPPLPEGLPI QPALDAWALG VLLFCLLTGY FPWDRPLAEA DPFYEDFLIW QASGQPRDRP QPWFGLAAAA DALLRGLLDP HPRRRSAVIA IREHLGRPWR QREGEAEAVG AVEEEAGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards