About Histone H2A-Bbd type 2/3
Histone H2A-Bbd type 2/3 (H2AB2) is a protein
from Homo sapiens identified by UniProt accession
P0C5Z0, 115 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Histone H2A-Bbd type 2/3 |
|---|
| UniProt accession | P0C5Z0 |
|---|
| Gene | H2AB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 115 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- congenital enteropathy due to enteropeptidase deficiency · score 0.04
- congenital lethal erythroderma · score 0.04
- Hereditary persistence of alpha-fetoprotein · score 0.04
- gastric mucosal hypertrophy · score 0.04
- Congenital deficiency in alpha-fetoprotein · score 0.03
- Hodgkins lymphoma · score 0.01
- neoplasm · score 0.01
- testicular seminoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C5Z0-F1 | alphafold | PREDICTED | 87.05 | — |
Amino-acid sequence (115 residues)
MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR TAPVYLAAVI EYLTAKVLEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST LFNTTTISQV APGED
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