About Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7 (USP17L7) is a protein
from Homo sapiens identified by UniProt accession
P0C7H9, 530 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7 |
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| UniProt accession | P0C7H9 |
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| Gene | USP17L7 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.10
- peak expiratory flow · score 0.05
- immunodeficiency 19 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.03
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.03
- severe combined immunodeficiency due to IKK2 deficiency · score 0.03
- ring chromosome Y · score 0.03
- X-Linked Combined Immunodeficiency Diseases · score 0.03
- severe combined immunodeficiency due to LAT deficiency · score 0.03
- obesity due to congenital leptin deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C7H9-F1 | alphafold | PREDICTED | 66.78 | — |
Amino-acid sequence (530 residues)
MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY TLPLSNYMLS REDSQTCHLH KCCMFCTMQA HITWALHSPG HVIQPSQVLA AGFHRGEQED AHEFLMFTVD AMKKACLPGH KQLDHHSKDT TLIHQIFGAY WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL VKPKELNGEN AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASGIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RPATQGELKR DHPCLQVPEL DEHLVERATQ ESTLDHWKFP QEQNKTKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP EQQSSLLNLS STKPTDQESM NTGTLASLQG STRRSKGNNK HSKRSLLVCQ
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