About Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 (USP17L8) is a protein
from Homo sapiens identified by UniProt accession
P0C7I0, 530 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8 |
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| UniProt accession | P0C7I0 |
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| Gene | USP17L8 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- hypertension · score 0.06
- immunodeficiency 19 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.03
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia · score 0.03
- severe combined immunodeficiency due to IKK2 deficiency · score 0.03
- ring chromosome Y · score 0.03
- X-Linked Combined Immunodeficiency Diseases · score 0.03
- severe combined immunodeficiency due to LAT deficiency · score 0.03
- obesity due to congenital leptin deficiency · score 0.03
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C7I0-F1 | alphafold | PREDICTED | 67.65 | — |
Amino-acid sequence (530 residues)
MEDDSLYLGG EWQFNHFSKL TSPRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY LNASLQCLTY TPPLANYMLS REHSQTCQRP KCCMLCTMQA HITWALHSPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL VKPEELNGEN AYPCGLCLQR APASNTLTLH TSAKVLILVL KRFCDVTGNK LAKNVQYPEC LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGYYFSYVK AQEGQWYKMD DAEVTACSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RPATQGELKR DHPCLQVPEL DEHLVERATE ESTLDHWKFP QEQNKMKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP EQQSSLLNLS SMNSTDQESM NTGTLASLQG RTRRSKGKNK HSKRSLLVCQ
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