Coiled-coil domain-containing protein 159 (CCDC159)

About Coiled-coil domain-containing protein 159

Coiled-coil domain-containing protein 159 (CCDC159) is a protein from Homo sapiens identified by UniProt accession P0C7I6, 297 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 159
UniProt accession	P0C7I6
Gene	CCDC159
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
Female infertility due to fertilization defect · score 0.07
Rare genetic female infertility · score 0.07
partial chromosome Y deletion · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
spermatogenic failure 3 · score 0.06
spermatogenic failure 55 · score 0.06
spermatogenic failure 31 · score 0.06
spermatogenic failure 53 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0C7I6-F1	alphafold	PREDICTED	76.74	—

Amino-acid sequence (297 residues)

MGEHEQVKPL ETSSSKVKAK TIVMIPDSQK LLRCELESLK SQLQAQTKAF EFLNHSVTML EKESCLQQIK IQQLEEVLSP TGRQGEKEEH KWGMEQGRQE LYGALTQGLQ GLEKTLRDSE EMQRARTTRC LQLLAQEIRD SKKFLWEELE LVREEVTFIY QKLQAQEDEI SENLVNIQKM QKTQVKCRKI LTKMKQQGHE TAACPETEEI PQGASGCWKD DLQKELSDIW SAVHVLQNSI DSLTLCSGAC PKASSLRGHK GHQCLSPPLP SWDSDSDCDQ DLSQPPFSKS GRSFPPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards