About Transmembrane protein 253
Transmembrane protein 253 (TMEM253) is a protein
from Homo sapiens identified by UniProt accession
P0C7T8, 217 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Transmembrane protein 253 |
|---|
| UniProt accession | P0C7T8 |
|---|
| Gene | TMEM253 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 217 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- erythrocyte count · score 0.10
- testosterone measurement · score 0.09
- red blood cell density measurement · score 0.09
- lean body mass · score 0.08
- hemoglobin measurement · score 0.08
- heart rate · score 0.08
- sitting height measurement · score 0.06
- hematocrit · score 0.06
- cortical thickness · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C7T8-F1 | alphafold | PREDICTED | 72.14 | — |
Amino-acid sequence (217 residues)
MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA VSVACLNSDC HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN TFNLILGFIV VVVEVMKTAL GPAPTASSQH AGLLVLELSA EAFTLGGVLV SVHALFLLSQ RKPGCCRSQS LHYQELQEGF SELEEVPGLE NGPTVASTGA NERVGQREQT RAALLPP
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