About Sperm microtubule associated protein 2-like
Sperm microtubule associated protein 2-like (SPMAP2L) is a protein
from Homo sapiens identified by UniProt accession
P0DJG4, 465 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Sperm microtubule associated protein 2-like |
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| UniProt accession | P0DJG4 |
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| Gene | SPMAP2L |
|---|
| Organism | Homo sapiens |
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| Length | 465 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- essential tremor · score 0.07
- metabolite measurement · score 0.06
- Young adult-onset Parkinsonism · score 0.06
- Intussusception · score 0.06
- Hereditary late-onset Parkinson disease · score 0.06
- Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.06
- X-linked dystonia-parkinsonism · score 0.06
- X-linked parkinsonism-spasticity syndrome · score 0.05
- spinocerebellar ataxia type 20 · score 0.05
- torsion dystonia 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DJG4-F1 | alphafold | PREDICTED | 63.40 | — |
Amino-acid sequence (465 residues)
MENQEFLSSS APSEVTDGQV STEISTCSEV FQKPIVLRIL DTHRELEESE DPEKHENPEE PEEVREQDQR DESEECDEPH ESYEPHAPYA PHKPRDSYAP YELHGPHAAP KLLKAREPRQ LRHTREPRKS REAKETELLP SAAVMISPSL ITRAPPRPQL SFLGANPVSC DFVRKCFSSR KRTPNLSKPK KQWGTPDRKL FWGNQDPIRP VSQGALKAQL TKRLENLAQP KEVSCHYVPN RAQYYHSCGR ESVIWEITPP ALFRQPSKRI QRLSQPNGFK RQCLLNRPFS DNSARDSLRI SDPSPRILQL SVAKGTDPNY HPSKKMQTKI SLSTLSAIAT PRIIELAHPR IKLEGLCYER QRSELPIRPV PPAAMIAKPS PRTIALAKSK SVHQDYLPDR DAHWPVSYAT THSKASPRIQ ELANPNKRAP VRIVYYDPDV FKTKPAALKA QCSQRIWELS QPLTR
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