About SLIT-ROBO Rho GTPase-activating protein 2B
SLIT-ROBO Rho GTPase-activating protein 2B (SRGAP2B) is a protein
from Homo sapiens identified by UniProt accession
P0DMP2, 458 residues long.
MolForge cross-references it against 0 known binders and
1 disease associations.
Target properties
| Protein name | SLIT-ROBO Rho GTPase-activating protein 2B |
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| UniProt accession | P0DMP2 |
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| Gene | SRGAP2B |
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| Organism | Homo sapiens |
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| Length | 458 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1)
Diseases linked to this target (Open Targets).
- Neurodevelopmental disorder · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DMP2-F1 | alphafold | PREDICTED | 88.55 | — |
Amino-acid sequence (458 residues)
MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE MDYSRNLEKL AERFLAKTCS TKDQQFKKDQ NVLSPVNCWN LLLNQVKRES RDHTTLSDIY LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK LKEAEKQEEK QIGKSVKQED RQTPRSPDST ANVRIEEKHV RRSSVKKIEK MKEKRQAKYT ENKLKAIKAR NEYLLALEAT NASVFKYYIH DLSDLIDCCD LGYHASLNRA LRTFLSAELN LEQSKHEGLD AIENAVENLD ATSDKQRLME MYNNVFCPPM KFEFQPHMGD MASQLCAQQP VQSELLQRCQ QLQSRLSTLK IENEEVKKTM EATLQTIQDI VTVEDFDVSD CFQYSNSMES VKSTVSETFM SKPSIAKRRA NQQETEQFYF TVRECYGF
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