About Transmembrane protein 225B
Transmembrane protein 225B (TMEM225B) is a protein
from Homo sapiens identified by UniProt accession
P0DP42, 221 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Transmembrane protein 225B |
|---|
| UniProt accession | P0DP42 |
|---|
| Gene | TMEM225B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 221 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- blood metabolite measurement · score 0.13
- myeloid white cell count · score 0.11
- body mass index · score 0.11
- leukocyte count · score 0.10
- serum metabolite measurement · score 0.10
- X12063 measurement · score 0.09
- hormone measurement · score 0.09
- platelet count · score 0.08
- testosterone measurement · score 0.07
- neutrophil count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DP42-F1 | alphafold | PREDICTED | 76.97 | — |
Amino-acid sequence (221 residues)
MLTLEDKDMK GFSWAIVPAL TSLGYLIILV VSIFPFWVRL TNEESHEVFF SGLFENCFNA KCWKPRPLSI YIILGRVFLL SAVFLAFVTT FIMMPFASEF FPRTWKQNFV LACISFFTGA CAFLALVLHA LEIKALRMKL GPLQFSVLWP YYVLGFGIFL FIVAGTICLI QEMVCPCWHL LSTSQSMEED HGSLYLDNLE SLGGEPSSVQ KETQVTAETV I
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