About Osteopontin
Osteopontin (SPP1) is a protein
from Homo sapiens identified by UniProt accession
P10451, 314 residues long.
MolForge cross-references it against 0 known binders and
1,328 disease associations.
Target properties
| Protein name | Osteopontin |
|---|
| UniProt accession | P10451 |
|---|
| Gene | SPP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 314 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1328)
Diseases linked to this target (Open Targets).
- bone density · score 0.39
- heel bone mineral density · score 0.37
- bone quantitative ultrasound measurement · score 0.35
- gout · score 0.34
- breast adenocarcinoma · score 0.25
- blood protein measurement · score 0.21
- non-small cell lung carcinoma · score 0.13
- hepatocellular carcinoma · score 0.13
- lung adenocarcinoma · score 0.13
- neoplasm · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10451-F1 | alphafold | PREDICTED | 53.41 | — |
Amino-acid sequence (314 residues)
MRIAVICFCL LGITCAIPVK QADSGSSEEK QLYNKYPDAV ATWLNPDPSQ KQNLLAPQNA VSSEETNDFK QETLPSKSNE SHDHMDDMDD EDDDDHVDSQ DSIDSNDSDD VDDTDDSHQS DESHHSDESD ELVTDFPTDL PATEVFTPVV PTVDTYDGRG DSVVYGLRSK SKKFRRPDIQ YPDATDEDIT SHMESEELNG AYKAIPVAQD LNAPSDWDSR GKDSYETSQL DDQSAETHSH KQSRLYKRKA NDESNEHSDV IDSQELSKVS REFHSHEFHS HEDMLVVDPK SKEEDKHLKF RISHELDSAS SEVN
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