About Cytochrome P450 2C8
Cytochrome P450 2C8 (CYP2C8) is a protein
from Homo sapiens identified by UniProt accession
P10632, 490 residues long.
MolForge cross-references it against 0 known binders and
223 disease associations.
Target properties
| Protein name | Cytochrome P450 2C8 |
|---|
| UniProt accession | P10632 |
|---|
| Gene | CYP2C8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 490 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (223)
Diseases linked to this target (Open Targets).
- blood metabolite measurement · score 0.41
- testosterone measurement · score 0.34
- cutaneous melanoma · score 0.30
- urinary metabolite measurement · score 0.30
- melanoma · score 0.22
- neutrophil percentage of leukocytes · score 0.21
- hepatocellular carcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.21
- serum metabolite measurement · score 0.21
- lung adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10632-F1 | alphafold | PREDICTED | 93.06 | — |
Amino-acid sequence (490 residues)
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV
Explore Cytochrome P450 2C8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets