About Heat shock cognate 71 kDa protein
Heat shock cognate 71 kDa protein (HSPA8) is a protein
from Homo sapiens identified by UniProt accession
P11142, 646 residues long.
MolForge cross-references it against 0 known binders and
351 disease associations.
Target properties
| Protein name | Heat shock cognate 71 kDa protein |
|---|
| UniProt accession | P11142 |
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| Gene | HSPA8 |
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| Organism | Homo sapiens |
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| Length | 646 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (351)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.47
- Red cell distribution width · score 0.46
- systemic lupus erythematosus · score 0.37
- mean corpuscular volume · score 0.35
- mean corpuscular hemoglobin · score 0.34
- reticulocyte count · score 0.33
- serum metabolite measurement · score 0.32
- HbA1c measurement · score 0.30
- neutrophil count · score 0.30
- myeloid white cell count · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11142-F1 | alphafold | PREDICTED | 88.30 | — |
Amino-acid sequence (646 residues)
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIINW LDKNQTAEKE EFEHQQKELE KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD
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