About Uridine 5'-monophosphate synthase
Uridine 5'-monophosphate synthase (UMPS) is a protein
from Homo sapiens identified by UniProt accession
P11172, 480 residues long.
MolForge cross-references it against 0 known binders and
119 disease associations.
Target properties
| Protein name | Uridine 5'-monophosphate synthase |
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| UniProt accession | P11172 |
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| Gene | UMPS |
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| Organism | Homo sapiens |
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| Length | 480 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (119)
Diseases linked to this target (Open Targets).
- orotic aciduria · score 0.75
- Hereditary orotic aciduria · score 0.72
- Intellectual disability · score 0.46
- mean platelet volume · score 0.40
- coronary artery disease · score 0.40
- heel bone mineral density · score 0.35
- platelet component distribution width · score 0.35
- cardiomyopathy · score 0.34
- mean corpuscular volume · score 0.34
- genetic disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11172-F1 | alphafold | PREDICTED | 92.14 | — |
Amino-acid sequence (480 residues)
MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADRL EAAEMYRKAA WEAYLSRLGV
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