Oteracil

Drug profile

Key facts

Oteracil is a drug catalogued in DrugCentral. It was first approved by the PMDA in 1999. DrugCentral lists 1 molecular target, including UMPS. Recorded indications include HER2-negative breast cancer, Hormone receptor pozitive breast cancer and Malignant tumor of stomach.

• Molecular targets: UMPS (1 listed in DrugCentral).
• Indications: HER2-negative breast cancer, Hormone receptor pozitive breast cancer and Malignant tumor of stomach.
• Molecular formula: C4H3N3O4; molecular weight 157.09 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• HER2-negative breast cancer
• Hormone receptor pozitive breast cancer
• Malignant tumor of stomach

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Uridine 5'-monophosphate synthase	UMPS	inhibitor	—

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2011-03-14	EMA	—	Nordic Group BV
1999-03-01	PMDA	—	Taiho Pharmaceutical Co, Ltd

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Disease progression	53.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Oteracil is on its molecule page.

• Molecular formula: C₄H₃N₃O₄
• Molecular weight: 157.09 g/mol
• CAS number: 937-13-3
• InChIKey: RYYCJUAHISIHTL-UHFFFAOYSA-N
• PubChem CID: 4604

OC(=O)C1=NC(=O)NC(=O)N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Oteracil used for?

DrugCentral lists the following indications for Oteracil: HER2-negative breast cancer, Hormone receptor pozitive breast cancer and Malignant tumor of stomach.

How does Oteracil work?

Its molecular targets in DrugCentral include UMPS (inhibitor).

When was Oteracil first approved?

Oteracil was first approved by the PMDA in 1999.

What is the chemical formula of Oteracil?

Oteracil has the molecular formula C4H3N3O4 and a molecular weight of 157.09 g/mol.

Sources

• DrugCentral drug card 2002 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL181932 — compound record and bioactivity
• PubChem CID 4604 — chemical identifiers
• DrugBank DB03209 — drug record
• FDA UNII 5VT6420TIG — substance identity
• UniProt P11172 (UMPS) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.