About Eosinophil peroxidase
Eosinophil peroxidase (EPX) is a protein
from Homo sapiens identified by UniProt accession
P11678, 715 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Eosinophil peroxidase |
|---|
| UniProt accession | P11678 |
|---|
| Gene | EPX |
|---|
| Organism | Homo sapiens |
|---|
| Length | 715 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (155)
Diseases linked to this target (Open Targets).
- eosinophil peroxidase deficiency · score 0.44
- eosinophil count · score 0.38
- neurodegenerative disease · score 0.36
- eosinophil percentage of leukocytes · score 0.33
- eosinophilic esophagitis · score 0.05
- myeloperoxidase deficiency · score 0.05
- neutropenia-monocytopenia-deafness syndrome · score 0.05
- hypertriglyceridemia 2 · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
- neutropenia, severe congenital, 2, autosomal dominant · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11678-F1 | alphafold | PREDICTED | 92.06 | — |
Amino-acid sequence (715 residues)
MHLLPALAGV LATLVLAQPC EGTDPASPGA VETSVLRDCI AEAKLLVDAA YNWTQKSIKQ RLRSGSASPM DLLSYFKQPV AATRTVVRAA DYMHVALGLL EEKLQPQRSG PFNVTDVLTE PQLRLLSQAS GCALRDQAER CSDKYRTITG RCNNKRRPLL GASNQALARW LPAEYEDGLS LPFGWTPSRR RNGFLLPLVR AVSNQIVRFP NERLTSDRGR ALMFMQWGQF IDHDLDFSPE SPARVAFTAG VDCERTCAQL PPCFPIKIPP NDPRIKNQRD CIPFFRSAPS CPQNKNRVRN QINALTSFVD ASMVYGSEVS LSLRLRNRTN YLGLLAINQR FQDNGRALLP FDNLHDDPCL LTNRSARIPC FLAGDTRSTE TPKLAAMHTL FMREHNRLAT ELRRLNPRWN GDKLYNEARK IMGAMVQIIT YRDFLPLVLG KARARRTLGH YRGYCSNVDP RVANVFTLAF RFGHTMLQPF MFRLDSQYRA SAPNSHVPLS SAFFASWRIV YEGGIDPILR GLMATPAKLN RQDAMLVDEL RDRLFRQVRR IGLDLAALNM QRSRDHGLPG YNAWRRFCGL SQPRNLAQLS RVLKNQDLAR KFLNLYGTPD NIDIWIGAIA EPLLPGARVG PLLACLFENQ FRRARDGDRF WWQKRGVFTK RQRKALSRIS LSRIICDNTG ITTVSRDIFR ANIYPRGFVN CSRIPRLNLS AWRGT
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