About Serum response factor
Serum response factor (SRF) is a protein
from Homo sapiens identified by UniProt accession
P11831, 508 residues long.
MolForge cross-references it against 0 known binders and
296 disease associations.
Target properties
| Protein name | Serum response factor |
|---|
| UniProt accession | P11831 |
|---|
| Gene | SRF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 508 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (296)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- cancer · score 0.10
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.10
- gonorrhea · score 0.10
- oral squamous cell carcinoma · score 0.08
- acute kidney failure · score 0.07
- axial length measurement · score 0.07
- breast cancer · score 0.06
- gastric ulcer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P11831-F1 | alphafold | PREDICTED | 51.96 | — |
Amino-acid sequence (508 residues)
MLPTQAGAAA ALGRGSALGG SLNRTPTGRP GGGGGTRGAN GGRVPGNGAG LGPGRLEREA AAAAATTPAP TAGALYSGSE GDSESGEEEE LGAERRGLKR SLSEMEIGMV VGGPEASAAA TGGYGPVSGA VSGAKPGKKT RGRVKIKMEF IDNKLRRYTT FSKRKTGIMK KAYELSTLTG TQVLLLVASE TGHVYTFATR KLQPMITSET GKALIQTCLN SPDSPPRSDP TTDQRMSATG FEETDLTYQV SESDSSGETK DTLKPAFTVT NLPGTTSTIQ TAPSTSTTMQ VSSGPSFPIT NYLAPVSASV SPSAVSSANG TVLKSTGSGP VSSGGLMQLP TSFTLMPGGA VAQQVPVQAI QVHQAPQQAS PSRDSSTDLT QTSSSGTVTL PATIMTSSVP TTVGGHMMYP SPHAVMYAPT SGLGDGSLTV LNAFSQAPST MQVSHSQVQE PGGVPQVFLT ASSGTVQIPV SAVQLHQMAV IGQQAGSSSN LTELQVVNLD TAHSTKSE
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