About Protein lyl-1
Protein lyl-1 (LYL1) is a protein
from Homo sapiens identified by UniProt accession
P12980, 280 residues long.
MolForge cross-references it against 0 known binders and
188 disease associations.
Target properties
| Protein name | Protein lyl-1 |
|---|
| UniProt accession | P12980 |
|---|
| Gene | LYL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 280 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (188)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- gliomatosis cerebri · score 0.37
- gastric carcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- monocyte count · score 0.35
- mean corpuscular volume · score 0.35
- mean corpuscular hemoglobin concentration · score 0.34
- mean platelet volume · score 0.33
- breast carcinoma · score 0.30
- monocyte percentage of leukocytes · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P12980-F1 | alphafold | PREDICTED | 65.61 | — |
Amino-acid sequence (280 residues)
MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR
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