Troponin T, slow skeletal muscle (TNNT1)

About Troponin T, slow skeletal muscle

Troponin T, slow skeletal muscle (TNNT1) is a protein from Homo sapiens identified by UniProt accession P13805, 278 residues long. MolForge cross-references it against 0 known binders and 255 disease associations.

Target properties

Protein name	Troponin T, slow skeletal muscle
UniProt accession	P13805
Gene	TNNT1
Organism	Homo sapiens
Length	278 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (255)

Diseases linked to this target (Open Targets).

nemaline myopathy 5 · score 0.75
nemaline myopathy 5B, autosomal recessive, childhood-onset · score 0.57
autosomal recessive nemaline myopathy · score 0.41
Amish nemaline myopathy · score 0.38
nemaline myopathy · score 0.38
body height · score 0.31
breast adenocarcinoma · score 0.23
head and neck squamous cell carcinoma · score 0.18
ovarian cancer · score 0.18
genetic disorder · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P13805-F1	alphafold	PREDICTED	74.05	—

Amino-acid sequence (278 residues)

MSDTEEQEYE EEQPEEEAAE EEEEAPEEPE PVAEPEEERP KPSRPVVPPL IPPKIPEGER VDFDDIHRKR MEKDLLELQT LIDVHFEQRK KEEEELVALK ERIERRRSER AEQQRFRTEK ERERQAKLAE EKMRKEEEEA KKRAEDDAKK KKVLSNMGAH FGGYLVKAEQ KRGKRQTGRE MKVRILSERK KPLDIDYMGE EQLRARSAWL PPSQPSCPAR EKAQELSDWI HQLESEKFDL MAKLKQQKYE INVLYNRISH AQKFRKGAGK GRVGGRWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards