Aldo-keto reductase family 1 member A1 (AKR1A1)

About Aldo-keto reductase family 1 member A1

Aldo-keto reductase family 1 member A1 (AKR1A1) is a protein from Homo sapiens identified by UniProt accession P14550, 325 residues long. MolForge cross-references it against 0 known binders and 294 disease associations.

Target properties

Protein name	Aldo-keto reductase family 1 member A1
UniProt accession	P14550
Gene	AKR1A1
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (294)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.42
glioblastoma multiforme · score 0.16
glomerular filtration rate · score 0.15
reticulocyte count · score 0.14
pulse pressure measurement · score 0.14
FEV/FVC ratio · score 0.12
reticulocyte measurement · score 0.11
serum metabolite measurement · score 0.11
blood protein measurement · score 0.09
protein measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14550-F1	alphafold	PREDICTED	96.86	—

Amino-acid sequence (325 residues)

MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards