About Gamma-aminobutyric acid receptor subunit alpha-1
Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1) is a protein
from Homo sapiens identified by UniProt accession
P14867, 456 residues long.
MolForge cross-references it against 0 known binders and
594 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-1 |
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| UniProt accession | P14867 |
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| Gene | GABRA1 |
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| Organism | Homo sapiens |
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| Length | 456 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (594)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 19 · score 0.75
- juvenile myoclonic epilepsy · score 0.74
- Seizure · score 0.63
- epilepsy · score 0.61
- unipolar depression · score 0.61
- insomnia · score 0.61
- panic disorder · score 0.60
- Agitation · score 0.60
- pain · score 0.60
- anxiety disorder · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P14867-F1 | alphafold | PREDICTED | 81.72 | — |
Amino-acid sequence (456 residues)
MRKSPGLSDC LWAWILLLST LTGRSYGQPS LQDELKDNTT VFTRILDRLL DGYDNRLRPG LGERVTEVKT DIFVTSFGPV SDHDMEYTID VFFRQSWKDE RLKFKGPMTV LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRITE DGTLLYTMRL TVRAECPMHL EDFPMDAHAC PLKFGSYAYT RAEVVYEWTR EPARSVVVAE DGSRLNQYDL LGQTVDSGIV QSSTGEYVVM TTHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GYAWDGKSVV PEKPKKVKDP LIKKNNTYAP TATSYTPNLA RGDPGLATIA KSATIEPKEV KPETKPPEPK KTFNSVSKID RLSRIAFPLL FGIFNLVYWA TYLNREPQLK APTPHQ
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