Alpidem
Drug profile
Also known as: ananxyl
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Alpidem is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1991. DrugCentral lists 6 molecular targets, including TSPO, Tspo and Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre. Recorded indications include Anxiety disorder.
- Molecular targets: TSPO, Tspo, Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre and ABCB11 (6 listed in DrugCentral).
- Indications: Anxiety disorder.
- Molecular formula: C21H23Cl2N3O; molecular weight 404.34 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Anxiety disorder
Mechanism & targets
Molecular targets (6)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Translocator protein | TSPO | unknown | Ki 9.30 |
| Translocator protein | Tspo | unknown | Ki 9.30 |
| GABA-A receptor; anion channel | Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre | unknown | IC50 7.59 |
| Bile salt export pump | ABCB11 | unknown | IC50 5.04 |
| Bile salt export pump | Abcb11 | unknown | IC50 4.64 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | GABRA1 | partial agonist | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1991-01-01 | YEAR INTRODUCED | — | — |
Chemical structure
| Molecular formula | C21H23Cl2N3O |
|---|---|
| Molecular weight | 404.34 g/mol |
| CAS number | — |
| InChIKey | JRTIDHTUMYMPRU-UHFFFAOYSA-N |
| PubChem CID | 54897 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Alpidem used for?
DrugCentral lists the following indications for Alpidem: Anxiety disorder.
How does Alpidem work?
Its molecular targets in DrugCentral include TSPO, Tspo, Gabrp|Gabrb1|Gabrd|Gabrg2|Gabra5|Gabra3|Gabrg1|Gabra2|Gabra4|Gabrg3|Gabra6|Gabra1|Gabrb3|Gabrb2|Gabrq|Gabre and ABCB11.
When was Alpidem first approved?
Alpidem was first approved by the YEAR INTRODUCED in 1991.
What is the chemical formula of Alpidem?
Alpidem has the molecular formula C21H23Cl2N3O and a molecular weight of 404.34 g/mol.
Browse: all drugs starting with A · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 134 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL54349 — compound record and bioactivity
- PubChem CID 54897 — chemical identifiers
- FDA UNII I93SC245QZ — substance identity
- UniProt P30536 (TSPO) — target protein
- UniProt O95342 (ABCB11) — target protein
- UniProt P14867 (GABRA1) — target protein
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