Translocator protein (TSPO)

About Translocator protein

Translocator protein (TSPO) is a protein from Homo sapiens identified by UniProt accession P30536, 169 residues long. MolForge cross-references it against 0 known binders and 428 disease associations.

Target properties

Protein name	Translocator protein
UniProt accession	P30536
Gene	TSPO
Organism	Homo sapiens
Length	169 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (428)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
multiple sclerosis · score 0.38
Parkinson disease · score 0.36
Alzheimer disease · score 0.36
lysosomal storage disease · score 0.36
monocyte count · score 0.35
leukocyte count · score 0.32
neutrophil count · score 0.30
monocyte percentage of leukocytes · score 0.28
myeloid white cell count · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30536-F1	alphafold	PREDICTED	66.31	—

Amino-acid sequence (169 residues)

MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFTTTL NYCVWRDNHG WRGGRRLPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards