D-amino-acid oxidase (DAO)

About D-amino-acid oxidase

D-amino-acid oxidase (DAO) is a protein from Homo sapiens identified by UniProt accession P14920, 347 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	D-amino-acid oxidase
UniProt accession	P14920
Gene	DAO
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (116)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.45
schizophrenia · score 0.39
Amyotrophic lateral sclerosis · score 0.37
familial amyotrophic lateral sclerosis · score 0.37
sporadic amyotrophic lateral sclerosis · score 0.37
blood protein measurement · score 0.23
neurodegenerative disease · score 0.22
genetic disorder · score 0.19
mean platelet volume · score 0.13
cognitive function measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P14920-F1	alphafold	PREDICTED	96.19	—

Amino-acid sequence (347 residues)

MRVVVIGAGV IGLSTALCIH ERYHSVLQPL DIKVYADRFT PLTTTDVAAG LWQPYLSDPN NPQEADWSQQ TFDYLLSHVH SPNAENLGLF LISGYNLFHE AIPDPSWKDT VLGFRKLTPR ELDMFPDYGY GWFHTSLILE GKNYLQWLTE RLTERGVKFF QRKVESFEEV AREGADVIVN CTGVWAGALQ RDPLLQPGRG QIMKVDAPWM KHFILTHDPE RGIYNSPYII PGTQTVTLGG IFQLGNWSEL NNIQDHNTIW EGCCRLEPTL KNARIIGERT GFRPVRPQIR LEREQLRTGP SNTEVIHNYG HGGYGLTIHW GCALEAAKLF GRILEEKKLS RMPPSHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards