Benzoic acid

Nitrogen Binding Agent

Key facts

Benzoic acid is a drug in the Nitrogen Binding Agent class catalogued in DrugCentral. Its mechanism of action is classified as Ammonium Ion Binding Activity. DrugCentral lists 3 molecular targets, including NAPRT, DAO and Slc22a20. Recorded indications include Dermatomyositis, Hyperammonemia, Induratio penis plastica and Morphea.

• Drug class: Nitrogen Binding Agent.
• Mechanism of action: Ammonium Ion Binding Activity.
• Molecular targets: NAPRT, DAO and Slc22a20 (3 listed in DrugCentral).
• Indications: Dermatomyositis, Hyperammonemia, Induratio penis plastica, Morphea and Pemphigus and others.
• Molecular formula: C7H6O2; molecular weight 122.12 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (6)

• Dermatomyositis
• Hyperammonemia
• Induratio penis plastica
• Morphea
• Pemphigus
• Systemic sclerosis

Contraindications (46)

• Achalasia of esophagus
• Acute nephropathy
• Anemia
• Anemia due to enzyme deficiency
• Anorexia nervosa
• Atony of colon
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Blood coagulation disorder
• Body fluid retention
• Breastfeeding (mother)
• Cardiovascular event risk
• Chronic heart failure
• Conduction disorder of the heart
• Deficiency of glucose-6-phosphate dehydrogenase
• Diabetes mellitus
• Disease of liver
• Disorder of autonomic nervous system
• Disorder of cardiovascular system
• Disorder of coronary artery
• Factor II deficiency
• Fever greater than 100.4 Fahrenheit
• Gastritis
• Gastroesophageal reflux disease
• Gastrointestinal hemorrhage
• Gastrointestinal ulcer
• Glaucoma
• Hemophilia
• Hepatic failure
• Hiatal hernia
• + 16 more

Mechanism & targets

• Mechanism of action (MoA): Ammonium Ion Binding Activity
• Established pharmacologic class: Nitrogen Binding Agent

Molecular targets (3)

Target	Gene	Action	Activity
Nicotinate phosphoribosyltransferase	NAPRT	unknown	Ki 8.72
D-amino-acid oxidase	DAO	unknown	Ki 5.70
Solute carrier family 22 member 20	Slc22a20	unknown	Ki 4.86

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Benzoic acid is on its molecule page.

• Molecular formula: C₇H₆O₂
• Molecular weight: 122.12 g/mol
• CAS number: 65-85-0
• InChIKey: WPYMKLBDIGXBTP-UHFFFAOYSA-N
• PubChem CID: 243

OC(=O)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Benzoic acid used for?

DrugCentral lists the following indications for Benzoic acid: Dermatomyositis, Hyperammonemia, Induratio penis plastica, Morphea, Pemphigus and Systemic sclerosis.

How does Benzoic acid work?

Benzoic acid is classified as Ammonium Ion Binding Activity; its molecular targets in DrugCentral include NAPRT, DAO and Slc22a20.

What drug class does Benzoic acid belong to?

Benzoic acid is in the Nitrogen Binding Agent class.

What is the chemical formula of Benzoic acid?

Benzoic acid has the molecular formula C7H6O2 and a molecular weight of 122.12 g/mol.

Sources

• DrugCentral drug card 4664 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL541 — compound record and bioactivity
• PubChem CID 243 — chemical identifiers
• DrugBank DB03793 — drug record
• FDA UNII 8SKN0B0MIM — substance identity
• DailyMed: FDA labels for Benzoic acid — current prescribing information (label search)
• UniProt Q6XQN6 (NAPRT) — target protein
• UniProt P14920 (DAO) — target protein

How this page is built: methodology · editorial policy & corrections.