Nicotinate phosphoribosyltransferase (NAPRT)
Homo sapiens — UniProt Q6XQN6
Data last refreshed: (UniProt release unknown)
Key facts
Nicotinate phosphoribosyltransferase (NAPRT) is a protein from Homo sapiens identified by UniProt accession Q6XQN6, 538 residues long. MolForge cross-references it against 12 known binders and 75 disease associations.
- UniProt accession: Q6XQN6; gene symbol NAPRT.
- Organism: Homo sapiens.
- Length: 538 amino acids.
- Top disease associations (Open Targets): metabolite measurement, Red cell distribution width and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nicotinate phosphoribosyltransferase |
|---|---|
| UniProt accession | Q6XQN6 |
| Gene | NAPRT |
| Organism | Homo sapiens |
| Length | 538 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- metabolite measurement · score 0.22
- Red cell distribution width · score 0.18
- protein measurement · score 0.14
- interleukin 18 measurement · score 0.12
- schizophrenia · score 0.12
- serum alanine aminotransferase measurement · score 0.12
- HbA1c measurement · score 0.10
- C-reactive protein measurement · score 0.10
- neoplasm · score 0.09
- cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6XQN6-F1 | alphafold | PREDICTED | 94.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6XQN6.
Amino-acid sequence (538 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NAPRT?
The strongest Open Targets associations for NAPRT are metabolite measurement, Red cell distribution width, protein measurement, interleukin 18 measurement and schizophrenia.
How long is the NAPRT protein?
The Homo sapiens NAPRT protein (UniProt Q6XQN6) is 538 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6XQN6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6XQN6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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