About Transcription factor 4
Transcription factor 4 (TCF4) is a protein
from Homo sapiens identified by UniProt accession
P15884, 667 residues long.
MolForge cross-references it against 0 known binders and
362 disease associations.
Target properties
| Protein name | Transcription factor 4 |
|---|
| UniProt accession | P15884 |
|---|
| Gene | TCF4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 667 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (362)
Diseases linked to this target (Open Targets).
- Pitt-Hopkins syndrome · score 0.84
- corneal dystrophy, Fuchs endothelial, 3 · score 0.71
- genetic disorder · score 0.55
- autism spectrum disorder · score 0.55
- schizophrenia · score 0.54
- Fuchs endothelial corneal dystrophy · score 0.51
- unipolar depression · score 0.51
- risk-taking behaviour · score 0.49
- Global developmental delay · score 0.48
- body height · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15884-F1 | alphafold | PREDICTED | 51.12 | — |
Amino-acid sequence (667 residues)
MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL PSSVYAPSAS TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG MLGNSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG IIGPSHNGAM GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ SATSPDLNPP QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD IKSITSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL AGPHPGMGDA SNHMGQM
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