About Beta-galactoside alpha-2,6-sialyltransferase 1
Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) is a protein
from Homo sapiens identified by UniProt accession
P15907, 406 residues long.
MolForge cross-references it against 0 known binders and
292 disease associations.
Target properties
| Protein name | Beta-galactoside alpha-2,6-sialyltransferase 1 |
|---|
| UniProt accession | P15907 |
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| Gene | ST6GAL1 |
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| Organism | Homo sapiens |
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| Length | 406 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (292)
Diseases linked to this target (Open Targets).
- serum IgG glycosylation measurement · score 0.49
- neurodegenerative disease · score 0.49
- type 2 diabetes mellitus · score 0.47
- COVID-19 · score 0.47
- blood protein measurement · score 0.41
- reticulocyte count · score 0.40
- eosinophil count · score 0.38
- alkaline phosphatase measurement · score 0.38
- reticulocyte measurement · score 0.37
- Immature Reticulocyte Fraction Measurement · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P15907-F1 | alphafold | PREDICTED | 88.12 | — |
Amino-acid sequence (406 residues)
MIHTNLKKKF SCCVLVFLLF AVICVWKEKK KGSYYDSFKL QTKEFQVLKS LGKLAMGSDS QSVSSSSTQD PHRGRQTLGS LRGLAKAKPE ASFQVWNKDS SSKNLIPRLQ KIWKNYLSMN KYKVSYKGPG PGIKFSAEAL RCHLRDHVNV SMVEVTDFPF NTSEWEGYLP KESIRTKAGP WGRCAVVSSA GSLKSSQLGR EIDDHDAVLR FNGAPTANFQ QDVGTKTTIR LMNSQLVTTE KRFLKDSLYN EGILIVWDPS VYHSDIPKWY QNPDYNFFNN YKTYRKLHPN QPFYILKPQM PWELWDILQE ISPEEIQPNP PSSGMLGIII MMTLCDQVDI YEFLPSKRKT DVCYYYQKFF DSACTMGAYH PLLYEKNLVK HLNQGTDEDI YLLGKATLPG FRTIHC
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