About Metalloproteinase inhibitor 2
Metalloproteinase inhibitor 2 (TIMP2) is a protein
from Homo sapiens identified by UniProt accession
P16035, 220 residues long.
MolForge cross-references it against 0 known binders and
766 disease associations.
Target properties
| Protein name | Metalloproteinase inhibitor 2 |
|---|
| UniProt accession | P16035 |
|---|
| Gene | TIMP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 220 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (766)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.40
- body height · score 0.36
- blood protein measurement · score 0.35
- gut microbiome measurement · score 0.33
- blood phosphate measurement · score 0.29
- hip bone size · score 0.25
- hip bone mineral density · score 0.25
- BMI-adjusted waist-hip ratio · score 0.24
- FEV/FVC ratio · score 0.23
- respiratory system disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16035-F1 | alphafold | PREDICTED | 91.11 | — |
Amino-acid sequence (220 residues)
MGAAARTLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND IYGNPIKRIQ YEIKQIKMFK GPEKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG KMHITLCDFI VPWDTLSTTQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE KNINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP
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