About Leukosialin
Leukosialin (SPN) is a protein
from Homo sapiens identified by UniProt accession
P16150, 400 residues long.
MolForge cross-references it against 0 known binders and
231 disease associations.
Target properties
| Protein name | Leukosialin |
|---|
| UniProt accession | P16150 |
|---|
| Gene | SPN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 400 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (231)
Diseases linked to this target (Open Targets).
- platelet count · score 0.35
- neurodegenerative disease · score 0.33
- platelet crit · score 0.31
- breast adenocarcinoma · score 0.18
- protein measurement · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- chronic lymphocytic leukemia · score 0.10
- diffuse large B-cell lymphoma · score 0.09
- neoplasm · score 0.09
- Sepsis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16150-F1 | alphafold | PREDICTED | 53.25 | — |
Amino-acid sequence (400 residues)
MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT SDPKADSTGD QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI KMSSVPQETP HATSHPAVPI TANSLGSHTV TGGTITTNSP ETSSRTSGAP VTTAASSLET SRGTSGPPLT MATVSLETSK GTSGPPVTMA TDSLETSTGT TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA STVPFRNPDE NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK SRQGSLAMEE LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP
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