About Pancreatic triacylglycerol lipase
Pancreatic triacylglycerol lipase (PNLIP) is a protein
from Homo sapiens identified by UniProt accession
P16233, 465 residues long.
MolForge cross-references it against 0 known binders and
218 disease associations.
Target properties
| Protein name | Pancreatic triacylglycerol lipase |
|---|
| UniProt accession | P16233 |
|---|
| Gene | PNLIP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 465 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (218)
Diseases linked to this target (Open Targets).
- obesity · score 0.57
- pancreatic triacylglycerol lipase deficiency · score 0.50
- type 2 diabetes mellitus · score 0.47
- Hepatitis · score 0.37
- Hepatic steatosis · score 0.37
- neuroinflammatory disorder · score 0.30
- infertility · score 0.26
- ovarian cancer · score 0.25
- lung adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P16233-F1 | alphafold | PREDICTED | 94.72 | — |
Amino-acid sequence (465 residues)
MLPLWTLSLL LGAVAGKEVC YERLGCFSDD SPWSGITERP LHILPWSPKD VNTRFLLYTN ENPNNFQEVA ADSSSISGSN FKTNRKTRFI IHGFIDKGEE NWLANVCKNL FKVESVNCIC VDWKGGSRTG YTQASQNIRI VGAEVAYFVE FLQSAFGYSP SNVHVIGHSL GAHAAGEAGR RTNGTIGRIT GLDPAEPCFQ GTPELVRLDP SDAKFVDVIH TDGAPIVPNL GFGMSQVVGH LDFFPNGGVE MPGCKKNILS QIVDIDGIWE GTRDFAACNH LRSYKYYTDS IVNPDGFAGF PCASYNVFTA NKCFPCPSGG CPQMGHYADR YPGKTNDVGQ KFYLDTGDAS NFARWRYKVS VTLSGKKVTG HILVSLFGNK GNSKQYEIFK GTLKPDSTHS NEFDSDVDVG DLQMVKFIWY NNVINPTLPR VGASKIIVET NVGKQFNFCS PETVREEVLL TLTPC
Explore Pancreatic triacylglycerol lipase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets